Sony Xperia i1 'Honami' poses for family photo

First leaked image allegedly shows upcoming 20-megapixel Sony 'cameraphone'

We've heard a good deal about the Sony "Honami" already — an upcoming camera-centric Sony smartphone said to pack a 20-megapixel Cyber-Shot camera and re-vamped camera software. The name "Xperia i1" has also been thrown around in reference to the device, which sources have told us is due to make an appearance sometime in Q3.

Today we could be getting our first look at the "Honami" — or Xperia i1 — courtesy of Brazilian site Techtudo. The outlet has snapped a couple of images of what it says is the Xperia i1, complete with 20-megapixel rear camera.  The hardware shown seems to employ Sony's "Omnibalance" design language — note the trademark trim design and rounded power button — while not matching any Sony phones we're familiar with.

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Source: http://feedproxy.google.com/~r/androidcentral/~3/AhDTnxIwSSY/story01.htm

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Supreme Court 2013: The Year in Review

Supreme Court Justice Samuel Alito at a National Italian American Foundation event in Washington in 2006

Photo by Jonathan Ernst/Reuters

Windsor v. United States, decided Wednesday, invalidates a provision of the Defense of Marriage Act that denies federal marriage benefits to same-sex couples. Justice Anthony Kennedy?s majority opinion points out that although laws as to who may marry (blood relatives? children?) differ quite a bit from state to state, federal benefits are uniform across states. That is, if a marriage is valid under one state?s law, that?s enough for the couple to qualify for those benefits, regardless of any differences between that state?s law and another state?s law. But DOMA, enacted in 1996, denied federal benefits to married same-sex couples even if their marriage was lawful. With telling quotations from the legislative history, Kennedy shows that DOMA?s denial of federal benefits to lawful same-sex marriages?alone among marriages?was motivated by a hostility that appears to have no basis related to any public interest. DOMA imposes both financial and psychological harm on same-sex married couples. The imposition is gratuitous. It comes close to saying: We?re not giving you money only because we don?t like you even though you?re loyal, law-abiding, and productive citizens. That sounds like a denial of equal protection, which the Supreme Court has long considered an implicit part of the due process clause of the Fifth Amendment (the due process clause that constrains federal as distinct from state action).

There is an analogy to public school segregation in the South before Brown v. Board of Education declared it unconstitutional: The motivation for segregation was hostility toward a minority, and the hostility had no justification in public policy. It was more sinister than DOMA because it was part of an elaborate, indeed an all-encompassing, system of official racial discrimination in Southern states. Gay people are no longer subject to systematic governmental discrimination. The part of DOMA at issue in the Windsor case is thus an anomaly. But its anomalousness is also cogent evidence that it?s unjustified. Gay sex is no longer illegal; its prohibition has been ruled unconstitutional. On what ground therefore should gay marriage be disfavored by the federal government?

An even closer analogy to Windsor is Loving v. Virginia, the case in which the Supreme Court in 1967 invalidated state laws forbidding interracial marriage. In that era, interracial marriage aroused the same antipathies that same-sex marriage does now (also primarily in Southern states, where polls show that disapproval of same-sex marriage is much higher than elsewhere). In neither case was there a reason, other than distaste, for forbidding the practice. DOMA does not forbid gay marriage. But it demotes it.

This discrimination against a historically despised, discriminated-against, and indeed often persecuted group requires justification. Justice Antonin Scalia, in his dissent, suggests that the justification is simplification of federal law. The federal agencies that dispense marital benefits will have to decide which same-sex marriages are valid. But this is true with respect to heterosexual marriages as well. Only couples whose marriage is valid are entitled to marital benefits. Marriage validity is rarely contested, but when it is, the contest is resolved at the state level: If a state allows a 13-year-old to marry her pet frog, and frog and girl move to another state, the state to which they move may decide not to recognize the marriage on the ground that it?s contrary to the public policy of the state. And then the couple will not be entitled to marital benefits. And likewise with a same-sex marriage. Down the road, courts may have to decide whether a state that refuses to permit its residents to marry someone of the same sex is obliged to recognize such a marriage contracted in another state that does permit same-sex marriage. However that issue is resolved, though, it won?t augment the burden on federal authorities of determining the validity of a marriage.

I should think a textualist-originalist such as Scalia would want to point out that there is no general prohibition of discrimination by the federal government anywhere in the Constitution or its amendments and no reference to sex or marriage, as well as that the Framers of the Constitution and its amendments would have considered a proposal to provide constitutional protection for gay sex acts, let alone for gay marriage or gay marriage benefits, preposterous. (Justice Samuel Alito, in a separate dissent, remarked the absence of any reference to marriage in the Constitution as support for DOMA?s constitutionality.) But Scalia?s silence is a comment on the limits of textualism and originalism. Once the Supreme Court, a decade ago in Lawrence v. Texas, provided constitutional protection for gay sex, same-sex marriage became (or should have been recognized as) a conservative policy, since conservatives like to channel sex into marriage. And with 13 states and the District of Columbia now authorizing gay marriage (eight of them within the past eight months), and more likely to follow as public opinion swings decisively in favor of allowing such marriage, the withholding of federal marital benefits becomes a senseless rearguard action, like Southern states? resistance in the 1960s to allowing interracial marriage. (The numbers: 53 percent of the adult population now favors the legalization of gay marriage, up from 27 percent in 1996, and the percentage rises to 70 percent for people between the ages of 18 and 29.) Scalia stated in his dissent that ?to defend traditional marriage is not to condemn, demean, or humiliate those who would prefer other arrangements.? But the ?defense? in the Defense of Marriage Act is actually an offense: a denial of federal benefits to ?those who would prefer other arrangements.?

Alito took a different tack. He said that some people think that gay marriage undermines heterosexual marriage. He doesn?t say how, and I don?t understand how. If it?s true, does this mean that heterosexual marriage undermines same-sex marriage? Does Alito think that straight people will become gay as a result of the invalidation of DOMA? Or does he hanker for the time when gay or lesbian people married ?straights? in order to conceal their true sexual identity? Alito is drawn to such arguments for DOMA as ?the institution of marriage was created for the purpose of channeling heterosexual intercourse into a structure that supports child rearing,? and ?marriage is essen?tially the solemnizing of a comprehensive, exclusive, per?manent union that is intrinsically ordered to producing new life, even if it does not always do so.? The first argument would have force only if one supposed (as virtually no one does any longer) that banning same-sex marriage would channel gays into straight marriages. The bearing of the second argument (a close paraphrase of official Vatican sex doctrine) eludes me. A sperm bank is intrinsically ordered to producing new life, even if it does not always do so. So what? A marriage of a man to a woman known to be sterile could not be thought intrinsically ordered to producing new life, yet it would surely be recognized by Alito as a valid marriage entitled to federal marital benefits. So far as yet appears, opposition to same-sex marriage, and to federal benefits for gay couples, is emotional and sectarian, rather than rational.

Source: http://www.slate.com/articles/news_and_politics/the_breakfast_table/features/2013/supreme_court_2013/supreme_court_and_doma_justice_alito_s_defense_is_all_emotion.html

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Whoa, What Makes This Chain of Beads Magically Float?

Here's a brilliant experiment you can do at home if you've got yourself a lengthy chain of metal beads, and a container big enough to hold them. You just take one end of the chain out and drop it so that it drags the rest with it, and almost immediately you'll see it rise up out of the container like it's magically defying gravity.

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Source: http://feeds.gawker.com/~r/gizmodo/full/~3/dfkuluc2I7c/whoa-what-makes-this-chain-of-beads-magically-float-596577212

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Helping RNA escape from cells' recycling process could make it easier to shut off disease-causing genes

June 24, 2013 ? Nanoparticles that deliver short strands of RNA offer a way to treat cancer and other diseases by shutting off malfunctioning genes. Although this approach has shown some promise, scientists are still not sure exactly what happens to the nanoparticles once they get inside their target cells.

A new study from MIT sheds light on the nanoparticles' fate and suggests new ways to maximize delivery of the RNA strands they are carrying, known as short interfering RNA (siRNA).

"We've been able to develop nanoparticles that can deliver payloads into cells, but we didn't really understand how they do it," says Daniel Anderson, the Samuel Goldblith Associate Professor of Chemical Engineering at MIT. "Once you know how it works, there's potential that you can tinker with the system and make it work better."

Anderson, a member of MIT's Koch Institute for Integrative Cancer Research and MIT's Institute for Medical Engineering and Science, is the leader of a research team that set out to examine how the nanoparticles and their drug payloads are processed at a cellular and subcellular level. Their findings appear in the June 23 issue of Nature Biotechnology. Robert Langer, the David H. Koch Institute Professor at MIT, is also an author of the paper.

One RNA-delivery approach that has shown particular promise is packaging the strands with a lipidlike material; similar particles are now in clinical development for liver cancer and other diseases.

Through a process called RNA interference, siRNA targets messenger RNA (mRNA), which carries genetic instructions from a cell's DNA to the rest of the cell. When siRNA binds to mRNA, the message carried by that mRNA is destroyed. Exploiting that process could allow scientists to turn off genes that allow cancer cells to grow unchecked.

Scientists already knew that siRNA-carrying nanoparticles enter cells through a process, called endocytosis, by which cells engulf large molecules. The MIT team found that once the nanoparticles enter cells they become trapped in bubbles known as endocytic vesicles. This prevents most of the siRNA from reaching its target mRNA, which is located in the cell's cytosol (the main body of the cell).

This happens even with the most effective siRNA delivery materials, suggesting that there is a lot of room to improve the delivery rate, Anderson says.

"We believe that these particles can be made more efficient. They're already very efficient, to the point where micrograms of drug per kilogram of animal can work, but these types of studies give us clues as to how to improve performance," Anderson says.

Molecular traffic jam

The researchers found that once cells absorb the lipid-RNA nanoparticles, they are broken down within about an hour and excreted from the cells.

They also identified a protein called Niemann Pick type C1 (NPC1) as one of the major factors in the nanoparticle-recycling process. Without this protein, the particles could not be excreted from the cells, giving the siRNA more time to reach its targets. "In the absence of the NPC1, there's a traffic jam, and siRNA gets more time to escape from that traffic jam because there is a backlog," says Gaurav Sahay, an MIT postdoc and lead author of the Nature Biotechnology paper.

In studies of cells grown in the lab without NPC1, the researchers found that the level of gene silencing achieved with RNA interference was 10 to 15 times greater than that in normal cells.

Lack of NPC1 also causes a rare lysosomal storage disorder that is usually fatal in childhood. The findings suggest that patients with this disorder might benefit greatly from potential RNA interference therapy delivered by this type of nanoparticle, the researchers say. They are now planning to study the effects of knocking out the NPC1 gene on siRNA delivery in animals, with an eye toward testing possible siRNA treatments for the disorder.

The researchers are also looking for other factors involved in nanoparticle recycling that could make good targets for possibly slowing down or blocking the recycling process, which they believe could help make RNA interference drugs much more potent. Possible ways to do that could include giving a drug that interferes with nanoparticle recycling, or creating nanoparticle materials that can more effectively evade the recycling process.

The research was funded by Alnylam Pharmaceuticals and the National Heart, Lung, and Blood Institute.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/7V-2JNR49qM/130624144824.htm

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Border security amendment clears hurdle, bolstering chances for immigration bill (Washington Post)

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Respawn Entertainment talks Xbox Live Cloud, praises its multiplayer servers

Microsoft's been quick to point out how it's beefing up the Xbox Live Cloud in preparation for its next wunderconsole, and now Respawn Entertainment is stepping in to detail just what Redmond's architecture means for multiplayer on Titanfall. The firm's Jon Shiring, who works with the game's cloud computing integration, says that the next-gen title boasts vastly improved online play since it leans on Ballmer and Company's cloud hardware instead of users to host sessions. By taking advantage of Microsoft's servers, the futuristic shooter benefits from more reliable bandwidth, snappier matchmaking times, extra CPU power and the elimination of latency-based host advantage and hacked-host cheating, to boot. Naturally, using dedicated servers can cost a ton, but Respawn says Microsoft managed to keep things comparatively inexpensive for developers, in part thanks to its Azure tech. For the dev's comprehensive write-up on just what this revamped Xbox Live architecture may mean for gaming, click the source link below.

Filed under: Gaming, HD, Microsoft

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Source: Respawn Entertainment

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/hvX6s50qqfw/

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Newtown marks 6 months since school massacre

Carlee Soto, front, and Jillian Soto, back, sisters of slain teacher Victoria Soto embrace during a ceremony on the six-month anniversary honoring the 20 children and six adults gunned down at Sandy Hook Elementary School on Dec. 14, 2012 in Newtown, Conn., Friday, June 14, 2013. Newtown held a moment of silence Friday for the victims of the massacre at Sandy Hook Elementary School at a remembrance event that doubled as a call to action on gun control, with the reading of names of thousands of victims of gun violence. (AP Photo/Jessica Hill)

Carlee Soto, front, and Jillian Soto, back, sisters of slain teacher Victoria Soto embrace during a ceremony on the six-month anniversary honoring the 20 children and six adults gunned down at Sandy Hook Elementary School on Dec. 14, 2012 in Newtown, Conn., Friday, June 14, 2013. Newtown held a moment of silence Friday for the victims of the massacre at Sandy Hook Elementary School at a remembrance event that doubled as a call to action on gun control, with the reading of names of thousands of victims of gun violence. (AP Photo/Jessica Hill)

People gather during a ceremony on the six-month anniversary honoring the 20 children and six adults gunned down at Sandy Hook Elementary school on Dec. 14, 2012 at Edmond Town Hall in Newtown, Conn., Friday, June 14, 2013. Newtown held a moment of silence Friday for the victims of the massacre at Sandy Hook Elementary School at a remembrance event that doubled as a call to action on gun control, with the reading of names of thousands of victims of gun violence. (AP Photo/Jessica Hill)

A teddy bear, flowers and a candle are the only items left at the entrance to Sandy Hook Elementary School on the six-month anniversary of the Dec. 14 shooting in Newtown, Conn., Friday, June 14, 2013. Newtown held a moment of silence Friday for the victims of the massacre at Sandy Hook Elementary School at a remembrance event that doubled as a call to action on gun control, with the reading of names of thousands of victims of gun violence. (AP Photo/Jessica Hill)

Ruth Goodsnyder of Sandy Hook, Conn., reacts during a ceremony on the six-month anniversary honoring the 20 children and six adults gunned down at Sandy Hook Elementary school on Dec. 14 in Newtown, Conn., Friday, June 14, 2013. Newtown held a moment of silence Friday for the victims of the massacre at Sandy Hook Elementary School at a remembrance event that doubled as a call to action on gun control, with the reading of names of thousands of victims of gun violence. Goodsnyder's granddaughter is student at the elementary school. (AP Photo/Jessica Hill)

Carlee Soto, left, and Jillian Soto, sisters of slain teacher Victoria Soto, hold hands during a 26-second moment of silence at Edmond Town Hall honoring the 20 children and six adults gunned down at Sandy Hook Elementary School on Dec. 14, 2012 in Newtown, Conn., Friday, June 14, 2013. Newtown held a moment of silence Friday for the victims of the massacre at Sandy Hook Elementary School at a remembrance event that doubled as a call to action on gun control, with the reading of names of thousands of victims of gun violence. (AP Photo/Jessica Hill)

NEWTOWN, Conn. (AP) ? The town where 20 children and six educators were massacred in December went silent for a moment Friday, six months later, at a remembrance event that doubled as a call to action on weapons control, with the reading of names of thousands of victims of gun violence.

The mood of the six-month marker was decidedly more political than private, with a group called Mayors Against Illegal Guns holding events in 10 states calling for lawmakers to expand background checks and urging senators who opposed the bill to reconsider.

Two sisters of slain teacher Victoria Soto addressed a crowd gathered at Edmond Town Hall in Newtown for a 26-second moment of silence, honoring the 20 children and six adults gunned down at the school on Dec. 14.

"This pain is excruciating and unbearable, but thanks to people like you, that come out and support us, we are able to get through this," said Carlee Soto, who hugged and held hands with her sister Jillian before taking the stage.

The event then transitioned to the reading of the names of more than 5,000 Americans killed with guns since the tragedy in Newtown. The reading of names was expected to take 12 hours.

Mayors Against Illegal Guns, which organized the event in Newtown, also launched a bus tour that will travel to 25 states over 100 days to build support for legislation to expand background checks for gun buyers. Such legislation failed in the Senate in April, and there are no indications it has gained traction over concerns about protecting gun rights.

The gunman in Newtown killed his mother and the 26 people at Sandy Hook Elementary School with a semiautomatic rifle, then committed suicide as police arrived. The shooting led some relatives of victims to campaign for tougher gun laws, including some who were in Washington this week lobbying lawmakers for action.

Jillian and Carlee Soto met with President Barack Obama as they campaigned for gun control.

"He just told us to have faith," said Jillian Soto, 24. "It isn't something that happens overnight. It's something that you have to continue to fight for. Within good time we will have this passed and we will have change."

Carlee Soto, who is 20, said they got back from Washington at 2 a.m. She said that the president and vice president spoke of waging a long battle and that she plans to continue her efforts, as well.

"It's a very tough battle to fight," she said. "It's very frustrating, but knowing I'm doing this for my sister and the other 25 and everyone else that's been affected by gun violence, it's worth it."

Teresa Rousseau, whose daughter Lauren was among the six educators killed at Sandy Hook, also met with the president this week. She said at first she wondered how she would survive, and now she knows she can and feels empowered as she campaigns for tougher gun laws.

"I think it's time the average American gets a little louder in what he has to say," Rousseau said.

Laura Miller was among many in the crowd wearing the school's green and white colors. She said that her son, a kindergartner, was unharmed but that his teacher was shot in the foot.

"I'm here for the people who were less fortunate than me," she said. "I think they're the bravest people in the world to be able to come out here and fight for change, and that's what we need to do. If more people come out, that's the only way anything is ever going to change."

The mayors group also held events in 10 states calling for lawmakers to expand background checks and urging senators who opposed the bill to reconsider. Those events, which include gun violence survivors and gun owners, were being in Arkansas, Arizona, Florida, Georgia, Indiana, Montana, North Carolina, New Hampshire, Ohio and Pennsylvania.

Suzanne Conway, 37, was among a handful of people who attended a rally in a Charlotte, N.C., park. The mother of four young children said the shooting compelled her to start a chapter of an anti-gun group, Moms Demand Action.

"Newtown hit me hard. I had to do something about it," she said. "People are not going to stop fighting. This is a very important issue."

In Indiana, about two dozen protesters gathered on the Monon Trail in Indianapolis and talked about pressing Indiana's congressional delegation to support background check legislation. Sen. Joe Donnelly, a Democrat, supports the checks, but Sen. Dan Coats, a Republican, does not.

The protest, held in a liberal swath of Republican Rep. Susan Brooks' district, should be about laying continued pressure on lawmakers, said Peter Luster, Indiana state director of Mayors Against Illegal Guns. Lawmakers have daily calls with their staff to check in on what constituents are talking about, and they should hear about background checks constantly, he said.

New York Mayor Michael Bloomberg, who co-founded the mayors group, this week sent a letter asking donors not to support Democratic senators who opposed the bill to expand background checks.

On the other side of the debate, the National Rifle Association is focusing on Sen. Joe Manchin, D-W.Va., who co-sponsored the bill to expand background checks, with a TV ad urging viewers to phone Manchin's office and tell him "to honor his commitment to the 2nd Amendment." The NRA plans to spend $100,000 airing the ad in West Virginia markets over the next two weeks.

___

Associated Press writers Mitch Weiss in North Carolina and Tom LoBianco in Indiana contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-06-14-Connecticut%20School%20Shooting/id-7ee848810c934f55855d81c12a178d48

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What do you think about the new look for iOS 7? [Poll]

The iOS 7 announcement at WWDC 2013 left us with a lot to talk about, but the most immediately noticeable difference is the appearance. Since Jony Ive took charge of the design, we had heard countless rumors about all the skeuomorphic elements being stripped out leaving us with a much simpler, flatter design. And that's pretty much what we got -- though if you look carefully at the press shots of Notes and Reminders, there's still a hint of paper in there. It's different, a whole lot different, but we want to know what you think of it.

The green felt has gone, the stitched leather has gone, the icons have been dramatically changed. iOS 7 is bright, colorful in places but reserved and simple in others. Billed as the biggest change to iOS since the introduction of the iPhone, there is no doubt that visually at least, those words are correct. But we want to hear your thoughts on it. Is it too flat? Too bright? Do you love it, hate it, or fall somewhere in between? Drop your vote in the poll up top and leave us your thoughts in the comments below.

Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/ObIR4Eq0oGs/story01.htm

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How Archaea might find their food: Sensor protein characterized

June 10, 2013 ? The microorganism Methanosarcina acetivorans lives off everything it can metabolise into methane. How it finds its sources of energy, is not yet clear. Scientists at the Ruhr-Universit?t Bochum together with colleagues from Dresden, Frankfurt, Muelheim and the USA have identified a protein that might act as a "food sensor." They characterised the molecule in detail and found both similarities and differences to the system that is responsible for the search for food in bacteria.

MsmS has a different function to that thought

The protein MsmS has so far only been studied from a bioinformatics point of view. Computer analyses of its gene sequence had predicted that it might be a phytochrome, i.e. a red light sensor. Using spectroscopic methods, the research team of the current study have refuted this theory. MsmS has a heme cofactor, like haemoglobin in red blood cells, and can, among other things, bind the substance dimethyl sulphide. This is one of the energy sources of Methanosarcina acetivorans. MsmS might thus serve the microorganism as a sensor to directly or indirectly detect this energy source. In genetic studies, the scientists also found evidence that MsmS regulates systems which are important for the exploitation of dimethyl sulphide.

Archaea: flexible "eaters"

Methanosarcina acetivorans belongs to the Archaea which constitute the third domain of life, alongside Bacteria and Eukarya; the term Eukarya comprising all living organisms with a cell nucleus. Many of them are adapted to extreme conditions or are able to use unusual energy sources. Among the organisms that live from methane production, the so-called methanogenic organisms, M. acetivorans is one of the most flexible when it comes to the choice of food sources. It converts many different molecules into methane, and thus produces energy. How M. acetivorans detects the different food sources, is still largely unknown.

In Archaea, unlike bacteria

For this purpose, bacteria use the so-called two-component system: when a sensor protein comes in contact with the food source, the protein modifies itself; it attaches a phosphate group to a certain amino acid residue, the histidine. The phosphate group is then transferred to a second protein. In methanogenic organisms such a process could trigger cellular processes that activate the methane production. Archaea might also use comparable sensor proteins in a way similar to bacteria. MsmS would be a candidate for such a task, because the analyses of the research team showed that it is able to transfer a phosphate residue to an amino acid. The target site of this phosphorylation is, however, probably not histidine. "So there could be differences between the signal transduction systems of Archaea and Bacteria" speculates Prof. Dr. Nicole Frankenberg-Dinkel from the work group Physiology of Microorganisms. "It is also interesting that the heme cofactor is covalently bound, i.e. linked with the protein by an electron-pair bond. This is very uncommon for sensor proteins which are present in the cell fluid."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/x9JPmr4yXJg/130610095030.htm

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Finest news source, as always (Unqualified Offerings)

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